Trivastal Retard 50

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Update Date 03/12/2020 . 4 mins read
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What is Trivastal® Retard (piribedil) used for?

Piribedil is used in the adjunctive symptomatic treatment of chronic pathological cognitive and neurosensorial deficits in elderly subjects (excluding Alzheimer’s disease and other dementia).

Adjunctive treatment of intermittent claudication in chronic obliterating arteriopathies of the lower limbs (in stage 2).

Proposed in ischaemic symptoms in ophthalmology.

Treatment of Parkinson’s disease:

  • Either as monotherapy (treatment of forms with predominant tremor);
  • In association with dopa-therapy from the outset, or secondarily, particularly in forms with tremor.

How should I take Trivastal® Retard (piribedil)?

This drug is best taken after a meal with a half glass of water. Swallow it whole, do not chew, crush, or dissolve it in liquid.

How do I store Trivastal® Retard (piribedil)?

Trivastal® Retard is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Trivastal® Retard in the bathroom or the freezer. There may be different brands of Trivastal® Retard that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Trivastal® Retard down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Trivastal® Retard (piribedil)?

While using this drug, tell your doctor if you have:

  • Excessive drowsiness
  • Sudden sleeping fits
  • Developing impulse control disorders including addictive gambling, excessive eating or spending, hypersexuality and increase in libido

Use in the elderly is restricted because of the risk of falls whether related to hypotension, sudden sleep onset, or confusional state.

It may impair the ability to drive or operate machinery.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Trivastal® Retard during pregnancy and breastfeeding. In the absence of relevant data, the use of this drug during pregnancy, and in women of childbearing age not using contraception is not recommended. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Trivastal® Retard (piribedil)?

Just like any other drug, piribedil can cause common side effects such as nausea, dizziness, confusion, and vomiting.

Rare side effects that need to be reported immediately include minor gastrointestinal problems like vomiting, flatulence and nausea among predisposed individuals.

Other uncommon symptoms may include orthostatic hypotension or drowsiness in predisposed persons.


What drugs may interact with Trivastal® Retard (piribedil)?

Trivastal® Retard may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Trivastal® Retard (piribedil)?

Trivastal® Retard may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Food improves the absorption of piribedil, so it is best to take it after your main meal for the day along with water. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Trivastal® Retard (piribedil)?

Trivastal® Retard may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Trivastal® Retard (piribedil)?

What is the dose of Trivastal® Retard (piribedil) for an adult?

The recommended dose is 1 tablet once a day, increasing to 2 tablets daily in 2 divided doses for severe cases. Dosage may be increased in Parkinson’s disease.

Monotherapy, the recommended dose is 3-5 tab in 3-5 divided doses daily, combination w/ dopa therapy 1-3 tab in 1-3 divided doses/day. Increase the dose gradually by 1 tab every 3 days to achieve these doses.

What is the dose of Trivastal® Retard (piribedil) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Trivastal® Retard (piribedil) available?

Trivastal® Retard is available in the following dosage forms and strengths:

  • Trivastal® Retard 50 SR tab 50 mg

What should I do in case of an emergency or overdose?

Given the emetic effect of piribedil at very high doses, overdosage is unlikely with the tablet form.

The signs of overdose are blood pressure instability (arterial hypertension or hypotension) and digestive symptoms which include nausea and vomiting.

These symptoms disappear on discontinuation of administration and with symptomatic treatment.

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Trivastal® Retard, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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