Methycobal (mecobalamin, vitamin B12)

Methycobal is the brand name of the drug mecobalamin or methylcobalamin. Mecobalamin is a form of vitamin B12.

Uses

What is Methycobal used for?

Methycobal is commonly treats:

• Vitamin B12 deficiency
• Megaloblastic anemia
• Peripheral neuropathy

How should I take Methycobal?

The oral tablet should be swallowed whole, without chewing or crushing it. Take it with or without meals.

The parenteral solution should be administered by a licensed healthcare professional. Throw away the ampule in the proper trash receptacle after use.

How do I store Methycobal?

This product is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. 

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & Warnings

What should I know before using Methycobal?

Before using this drug, tell your doctor if you are/have:

• Pregnant or breastfeeding.
• Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
• An allergy to any of the ingredients of this product.
• Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. However, it is likely safe to take. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

Side Effects

What side effects can occur from Methycobal?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

• Allergic reaction
• Loss of appetite (anorexia)
• Nausea
• Vomiting
• Diarrhea

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Methycobal?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. 

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. 

Drugs with known interactions:

• Chloramphenicol
• Methotrexate
• Pyrimethamine
• Antibiotics

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with Methycobal?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Don’t drink alcohol while taking this drug because it can reduce vitamin B12 levels. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Methycobal?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Peripheral Neuropathies 

Oral: 3 tablets daily in 3 divided doses. 

Parenteral: 1 ampule IM or IV 3 times per week. 

Megaloblastic Anemia 

Parenteral: 1 ampule IM or IV 3 times per week. 

• After 2 months, reduced to single administration of 1 ampule at 1-3 month interval as maintenance.

What is the dose for a child?

There is no established pediatric dose. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Methycobal available?

Methycobal is available in the following dosage forms and strengths:

• Solution for injection (glass ampule): 500 mcg/1 mL
• Tablet: 500 mcg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.