Tixocortol is part of a class of drugs known as corticosteroids. Corticosteroids, or steroids, are synthetic drugs that are modeled after the naturally occurring hormone cortisol, which is produced in the adrenal glands located above the kidneys. Corticosteroids are used to reduce inflammation, pain, itchiness, and other effects mediated by the immune system response.

Tixocortol is mainly indicated to treat the following conditions:

  • Allergic rhinitis
  • Seasonal rhinitis
  • Acute congestive rhinitis
  • Chronic congestive rhinitis
  • Vasomotor rhinitis

How should I take tixocortol?

Tixocortol is available as a nasal suspension. Clean and dry the inside of your nose with a tissue before using this medication. Remove the cap of the spray bottle and insert the nozzle into your nostril and spray the solution. Repeat in the other nostril and recap the bottle.

Do not share this medication with anyone, even if they have been diagnosed with rhinitis or have similar symptoms as you.

How do I store tixocortol?

This drug should be stored at room temperature (<30°C) and be protected from light and moisture. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & Warnings

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to tixocortol or other corticosteroids.
  • You have a history of allergy to other medications, food, or other substances.
  • You are taking other medications, especially other corticosteroids.
  • You have underlying health conditions, especially any active infections.

Is it safe during pregnancy or breastfeeding?

This drug is a pregnancy category C drug. There is insufficient evidence from human studies that shows it can cause fetal harm when taken during pregnancy. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

As a nasal suspension, this drug is not likely to pass in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side Effects

All drugs have the potential to elicit side effects even with normal use. Many side effects are route and dose-related and will likely resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Hypersensitivity
  • Nasal dryness
  • Rhinalgia
  • Epistaxis
  • Angioedema
  • Blurred vision
  • Facial edema

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.


This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.

If you experience an adverse drug interaction stop taking this drug. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with tixocortol?

There are no known food or alcohol interactions with tixocortol.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with tixocortol?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Infected rhinitis

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.


The information provided is not a substitute for any medical advice. You should ALWAYS consult your doctor or pharmacist before using tixocortol.

What is the dose of tixocortol for an adult?

For treating rhinitis

  • Actuate 1 to 2 pulverizations into each nostril 2 to 4 times a day, as directed by your doctor.

What is the dose of tixocortol for a child?

This drug is not recommended for use in children and the recommended dose has not been established. Consult a doctor or pharmacist for alternatives and more information.

How is tixocortol available?

This drug is available in the following brands, dosage forms, and strengths:

  • Pivalone 1% nasal suspension

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Written by

Stephanie Nera, RPh, PharmD


Updated Dec 03, 2020