Uses
What is manidipine used for?
Manidipine is part of a class of drugs known as antihypertensives, specifically a dihydropyridine -type calcium channel blocker (CCBs). While calcium is best known as the essential component in bones and teeth, calcium is also a cation or electrolyte that plays an important role in muscle contraction.
CCBs reduce the amount of calcium that enters the heart muscle and endothelial (blood vessel) cells, which slows down contractions and dilates the blood vessels, consequently lowering blood pressure. Manidipine is a long-acting CCB and its hypertension-controlling effects typically last for an entire day.
Manidipine is mainly indicated to treat the following conditions:
- Hypertension
How should I take manidipine?
Manidipine is available as an oral tablet. The oral tablet should be taken by mouth without chewing or crushing it. The tablet should be taken with food, preferably at breakfast time.
How do I store manidipine?
This drug should be stored at room temperature (<30°C) and be protected from light and moisture. Always check the label before using this product. For safety, keep out of the reach of children and pets.
Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.
Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.
Precautions & Warnings
What should I know before using manidipine?
Calcium channel blockers, including manidipine, are associated with an increased risk of hypotension. This risk is further increased in older patients usually over 60 years of age and those taking other medications that cause vasodilation.
Some calcium channel blockers may alter the response to insulin and glucose responses in patients with both hypertension and diabetes mellitus.
Before using this medication, inform your doctor if:
- You have ever had an allergic reaction to manidipine or other calcium channel blockers.
- You have a history of allergy to other medications, food, or other substances.
- You are taking other medications, especially other antihypertensives.
- You have underlying health conditions such as diabetes.
Is it safe during pregnancy or breastfeeding?
This drug should not be given to women who are pregnant. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.
This drug may be excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.
Side Effects
What side effects can occur when using manidipine?
All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.
Potential side effects while using this drug include:
- Peripheral edema
- Headache
- Palpitation
- Flushing
- Dizziness
- Rash
- Fatigue
- Eye pain
- Temporary blindness
- Increased frequency of urination
- Depression
- Impotence
Seek medical attention immediately if you experience any of these serious, potentially fatal drug reactions:
- Ischemic heart pain
- Brain or heart ischemia
You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.
Interactions
What drugs may interact with manidipine?
This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.
Known drugs and their interactions with manidipine include:
- Other antihypertensives
- Enhanced hypotension
- Diuretics
- Enhanced hypotension
- Hyperkalemia (with potassium-sparing diuretics)
- Aldesleukin
- Enhanced hypotension
- Antipsychotics
- Enhanced hypotension
- Nitrates
- Enhanced hypotension
- Carbamazepine, phenytoin
- Decreased plasma concentration of manidipine
- Rifampicin
- Decreased plasma concentration of manidipine
- Cimetidine
- Increased plasma concentration of manidipine
- Erythromycin
- Increased plasma concentration of manidipine
If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.
Does food or alcohol interact with manidipine?
This drug may interact with grapefruit juice. Do not take this drug together with grapefruit or other food and supplements that contain grapefruit juice. This drug should not be taken with alcohol as it may increase the severity of hypotension.
Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.
What health conditions may interact with manidipine?
This drug should be taken with caution if you have any of the following conditions or risk factors:
- Hypotension
- Poor cardiac reserve
- Heart failure
- Cardiogenic shock
- Recent heart attack
- Acute unstable angina
- Severe aortic stenosis
- Porphyria
Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.
Dosage
The information provided is not a substitute for any medical advice. You should ALWAYS consult your doctor or pharmacist before using manidipine.
What is the dose of manidipine for an adult?
For hypertension
- Take 10-20 mg per day by mouth and with a meal.
What is the dose of manidipine for a child?
This drug is not recommended for use in children and the recommended dose has not been established. Consult with a doctor or pharmacist for alternatives and more information.
How is manidipine available?
This drug is available in the following dosage forms and strengths:
- Tablet 10 mg, 20 mg
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
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