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Idoxuridine ophthalmic solution

Written by Stephanie Nera, RPh, PharmD · Pharmacology

Updated Sep 03, 2020


What is idoxuridine ophthalmic solution used for?

Idoxuridine ophthalmic is indicated in the treatment of keratitis caused by herpes simplex virus (HSV) and vaccinia virus. It is used to treat eye infections.

How should I take idoxuridine ophthalmic solution?

Idoxuridine ophthalmic solution is available as an eyedrop preparation. To use the eye drops, follow these instructions:

  • Wash your hands thoroughly with mild soap and water.
  • Remove the protective cap on the bottle. Make sure that the end of the dropper is not chipped or cracked and that the eye drops are not cloudy.
  • Avoid touching the dropper tip against your eye or anything else.
  • Hold the dropper tip down at all times to prevent drops from flowing back into the bottle and contaminating the remaining contents.
  • Lie down or tilt your head back.
  • Holding the bottle between your thumb and index finger, place the dropper tip as near as possible to your eyelid without touching it.
  • Brace the remaining fingers of that hand against your cheek or nose.
  • With the index finger of your other hand, pull the lower lid of the eye down to form a pocket.
  • Drop the prescribed number of drops into the pocket made by the lower lid and the eye.
  • Placing drops on the surface of the eyeball can cause stinging.
  • Close your eye and press lightly against the lower lid with your finger for 2-3 minutes to keep the medication in the eye. Do not blink.
  • Replace and tighten the cap right away. Do not wipe or rinse it off.
  • Wipe off any excess liquid from your cheek with a clean tissue. Wash your hands again.

How do I store idoxuridine ophthalmic?

Idoxuridine ophthalmic solution should be stored in the refrigerator or at controlled room temperature (2-25°C) and be protected from light and moisture. Do not freeze it. For safety, keep out of the reach of children and pets.

Always check the label before using this product. Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & Warnings

What should I know before using idoxuridine ophthalmic solution?

Before using idoxuridine ophthalmic solution, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of the active or inactive ingredients of idoxuridine ophthalmic or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Idoxuridine ophthalmic solution is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

There are no adequate studies in women for determining risk when using idoxuridine ophthalmic during pregnancy or while breastfeeding.

Always consult with your doctor to discuss the potential benefits and risks before using idoxuridine ophthalmic solution.

Side Effects

All medications have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this supplement include:

  • Eye irritation or pain
  • Redness
  • Itching
  • Swelling of the eye
  • Increased sensitivity to light

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.


Idoxuridine ophthalmic may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.

Does food or alcohol interact with idoxuridine ophthalmic solution?

Idoxuridine ophthalmic may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects.

Contact your doctor or a pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with idoxuridine ophthalmic solution?

Idoxuridine ophthalmic may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult your doctor or pharmacist before using idoxuridine ophthalmic solution.

What is the dose of idoxuridine ophthalmic solution for an adult?

Herpes simplex

As 0.1% solution: Instill 1 drop in the affected eye(s) every hour. Decrease the dosing to every 2 hours or 4 times per day. Continue treatment for at least 7 days.

What is the dose of idoxuridine ophthalmic solution for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using it. Please consult with your doctor or pharmacist for more information.

How is idoxuridine ophthalmic solution available?

Idoxuridine ophthalmic is available in the following dosage forms and strengths:

  • Eyedrop solution 0.1 %

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of idoxuridine ophthalmic, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


Hello Health Group does not provide medical advice, diagnosis or treatment.

Written by

Stephanie Nera, RPh, PharmD


Updated Sep 03, 2020

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