Eligard (leuprorelin) is part of a class of drugs known as antineoplastics or anti-cancer drugs. Leuprorelin is a luteinizing hormone-releasing hormone (LHRH) agonist used to manage certain cancers. As an LHRH agonist, it works by binding to receptors on target tissues, resulting in lower levels of sex hormones such as testosterone.

Eligard is indicated to treat the following conditions:

  • Advanced prostate cancer

How should I take Eligard?

Eligard is available as a solution for subcutaneous (SQ) injection. It should be administered by a licensed health professional.

How do I store Eligard?

This product should be stored in a refrigerator (2-8°C). Once removed from the refrigerator, the product can be stored at room temperature (15-30°C) for up to 8 weeks, prior to administration. Do not freeze this product.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & Warnings

Eligard may cause a “tumor flare.” This means that there is a transient increase in testosterone levels during the start of treatment. The surge of testosterone is temporary, however, may worsen symptoms.

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to this medication
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications
  • You have underlying health conditions

Is it safe during pregnancy or breastfeeding?

Eligard is mainly indicated for prostate cancer in men, thus the pregnancy category does not apply in this case. This drug may cause fetal harm when administered to a pregnant woman. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug may be excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side Effects

What side effects can occur when using Eligard?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Burning, pain, bruising, or redness at the injection site
  • Malaise
  • Fatigue
  • Weakness
  • Dizziness
  • Hot flashes
  • Urinary frequency
  • Nocturia
  • Nausea
  • Gastroenteritis/colitis
  • Pruritis
  • Night sweats
  • Alopecia (hair loss)
  • Muscle or joint pain
  • Testicular atrophy (shrinking)
  • Gynecomastia
  • Testicular pain
  • Decreased libido
  • Infertility

You may experience some, none, or other side effects not mentioned above. If you experience serious adverse reactions, you must stop taking the drug immediately. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.


This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with Eligard?

This drug can be taken with or without meals, as there are no notable interactions. There are no notable interactions with alcohol with this drug, though it should be avoided or minimized.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with Eligard?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Diabetes mellitus or hyperglycemia
  • Cardiovascular diseases
  • History of seizures or cerebrovascular disorders

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.


The information provided is not a substitute for any medical advice. You should ALWAYS consult your doctor or pharmacist before using Eligard.

What is the dose of Eligard for an adult?

To treat advanced prostate cancer

  • Administer each dose subcutaneously. The frequency of dosing is dependent on the recommended dose.
    • One 7.5 mg injection every month
    • One 22.5 mg injection every 3 months
    • One 30 mg injection every 4 months
    • One 45 mg injection every 6 months

What is the dose of Eligard for a child?

The recommended dose for pediatric patients has not been established. Ask your doctor or pharmacist for available substitutes and more information on this drug.

How is Eligard available?

This drug is available in the following dosage forms and strengths:

  • Pre-filled syringe with suspension for injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Written by

Stephanie Nera, RPh, PharmD


Updated Dec 03, 2020