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Colorectal Cancer Staging: Identifying the Stages and What They Mean

    Colorectal Cancer Staging: Identifying the Stages and What They Mean

    Cancer is a word that strikes fear in many people, and over time, it only gets more alarming as it affects other parts of the body. However, diagnosing it early can make a world of difference by improving survival and increasing options for treatment. Read on to better understand colorectal cancer staging and how it plays a significant role in the course of cancer management.

    What Is Colorectal Cancer?

    Colorectal cancer is a type of cancer that occurs in the middle-lower part of the digestive system, specifically in the colon or rectum. Some also refer to it as colon cancer or rectal cancer, depending on where the cancer cells begins to grow.

    Most of the time, colorectal cancer begins as tiny precancerous polyps (adenomatous or serrated). Typically, these polyps develop slowly and do not display symptoms until they become large or malignant. This makes the diagnosis and treatment of pre-cancerous polyps prior to the formation of cancer difficult. Thus, it is critical to get regular screenings to detect the cancer, and also determine the colorectal cancer staging if it is found.

    Signs and Symptoms of Colorectal Cancer

    Despite not being evident early on, some signs and symptoms may include the following:

    • Constipation
    • Diarrhea
    • Bowel incontinence
    • Narrowing of stools
    • Blood in the stool
    • Unexplained anemia
    • Abdominal or pelvic pain (may also lead to bloating)
    • Unexplained weight loss
    • Vomiting

    These signs may help the doctor evaluate your medical condition in the process of colorectal cancer staging.

    Diagnosis: Evaluation and Screening Tests

    There are a different screening tests your doctor may discuss with you according to your evaluation. These may include:

    • Stool tests such as
      • Guiac-based Fecal Occult Blood Test (gFOBT)
      • Fecal Immunochemical Test (FIT)
      • FIT-DNA test or the stool DNA test
    • Flexible sigmoidoscopy
    • Colonoscopy
    • CT Colonography (Virtual Colonoscopy)

    Your doctor will also do a physical examination and health history check to better assess and understand your medical condition.

    Colorectal Cancer Staging: TNM Staging

    The American Joint Committee on Cancer developed a system that could stage the development of colorectal cancer in a person’s body. This Tumor, Node, and Metastasis (TNM) system classifies the different stages based on the following considerations:

    1. Tumor’s size (T) and how deeply it has spread into the colon or rectum tissues
    • T1 – Tumor is detected in the bowel’s inner layer.
    • T2 – Tumor has spread into the gut wall’s muscle layer.
    • T3 – Tumor has progressed to the intestinal wall’s outer lining.
    • T4 – Tumor has grown through the intestinal wall’s outer lining.
    1. Malignancy that migrated to some of the neighboring lymph nodes (N)
    • N0 – No cancer cells found in lymph nodes.
    • N1 – Cancer cells in up to three lymph nodes within the area.
    • N2 – Cancer cells in four or more lymph nodes within a short distance.
    1. How cancer has spread (metastasized) to other organs of the body (M)
    • M0 – Malignancy has not spread to other regions of the body.
    • M1 – Cancer has progressed to other organs, such as the liver or lungs.

    For instance, your diagnosis could be “T3N1M0.” This indicates that cancer has migrated from the bowel’s outer lining to up to three surrounding lymph nodes, but not to other areas of the body.

    Furthermore, the TNM staging report is occasionally written with a lower case letter in front of it. cTNM denotes that the report is based on clinical data. This is based on scans and biopsies performed before to the start of treatment. On the other hand, pTNM indicates that the report is based on the complete findings of both the pre-treatment and post-surgery investigations. It may also include some pathological assessments of tissue under the microscope.

    Colorectal Cancer Staging: Number Staging

    The system also determines what stage the cancer is in — the earliest stage of colorectal cancer which is 0, or any of the other four primary stages. Substages that fall under some of the main stages (like stage 2A or 2B) describe specific features. It may also suggest the locality of the cancer cells.

    Stage 0 (Carcinoma in Situ)

    During this early stage, abnormal cells are discovered in the mucosa (innermost layer) of the colon wall. These abnormal cells may develop into cancer and spread to other normal tissues nearby. Carcinoma in situ is another term for stage 0 cancer.

    Stage 1

    The next stage directs progression to the submucosa (tissue layer adjacent to the mucosa) or the muscle layer of the colon wall.

    Stage 2

    Colon cancer in stage 2 is classified into three stages: 2A, 2B, and 2C.

    • Stage 2A: Cancer has affected the serosa (outermost layer) of the colon wall from the muscle layer.
    • Stage 2B: Cancer has spread to the tissue that lines the organs in the abdomen through the serosa (outermost layer) of the colon wall (visceral peritoneum).
    • Stage 2C: Cancer is scattered to the adjacent organs through the serosa (outermost layer) of the colon wall.

    Stage 3

    In this advanced stage, cancer has spread to the lymph nodes. Colon cancer in stage 3 is also classified into three different stages — 3A, 3B, and 3C. The only difference between these three is in terms of their progressive severity. It also describes how many lymph nodes are already affected within the area, either 1-3 or 4-6.

    Stage 4

    By stage 4, cancer has spread to distant organs. The fourth and final stage also takes into account several different sub-stages.

    • Stage 4A: Cancer has progressed to one region or organ, such as the liver, lungs, ovaries, or distant lymph nodes.
    • Stage 4B: Cancer has spread to more than one region or organ. Just like stage 4A, it may also involve the liver, lung, ovary, or a distant lymph node.
    • Stage 4C: Cancer has reached the tissue that borders the abdominal wall and may have spread to other organs or areas of the body.

    Key Takeaway

    Colorectal cancer staging is an important tool in determining the severity of cancer and finding the right treatment. More than anything, it is important to see your doctor if you’re experiencing any signs or symptoms. Early detection and treatment of colorectal cancer can save lives.

    Learn more about colorectal cancer here.

    Hello Health Group does not provide medical advice, diagnosis or treatment.

    Sources

    Colorectal (Colon)  Cancer, https://my.clevelandclinic.org/health/diseases/14501-colorectal-colon-cancer, Accessed November 5, 2021

    Colorectal Cancer Screening Tests, https://www.cdc.gov/cancer/colorectal/basic_info/screening/tests.htm, Accessed November 5, 2021

    Colorectal Cancer Stages, https://www.cancercenter.com/cancer-types/colorectal-cancer/stages, Accessed November 5, 2021

    Colon Cancer Treatment Treatment (PDQ®)–Patient Version, https://www.cancer.gov/types/colorectal/patient/colon-treatment-pdq, Accessed November 5, 2021

    Staging and grading, https://www.bowelcanceruk.org.uk/about-bowel-cancer/diagnosis/staging-and-grading/, Accessed November 5, 2021

    TNM Staging, https://www.cancerresearchuk.org/about-cancer/bowel-cancer/stages-types-and-grades/TNM-staging, Accessed November 5, 2021

    Picture of the authorbadge
    Written by Fiel Tugade Updated Jul 13
    Medically reviewed by John Paul Abrina, MD
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