Does COVID affect men more than women? Experts believe that our biological gender somehow has a hand in whether or not we’ll develop mild or severe COVID-19 symptoms.
Study: COVID-19 Mutation Found to Be More Infectious
Does COVID affect men more than women? Experts believe that our biological gender somehow has a hand in whether or not we’ll develop mild or severe COVID-19 symptoms.
Study: COVID-19 Mutation Found to Be More Infectious
Sometime in the stretch of this pandemic, you might have heard about the possibility of women being more immune against COVID-19 than men. And you might be a little confused as to what that means.
First off, it doesn’t mean that women are less likely to contract the virus than men. It’s more like women are less likely to develop severe symptoms of COVID. But where did this idea come from?
The idea came from case reports submitted by various countries. For instance, the World Health Organization (WHO) back in February 2020 stated that the death rate among COVID-positive patients in China was only 2.8% among women but 4.7 % in men.
Other countries also submitted the following similar findings:
The staggering statistics which denote the difference between men and women prompted several scientists to dig into the potential reasons why.
Is COVID More Severe When You’re Pregnant?
As of now, the field of medicine still cannot offer the exact reason why COVID seems to hit men harder than women.
However, researchers have some scientific speculations that it’s because of the stronger nature of women’s immune response.
Let’s explain the nature of the differences:
Why does COVID-19 affect men more than women? It might have something to do with women’s innate and adaptive immune response. So, before we proceed further, let’s differentiate the two.
One of the components of our innate immune response is called toll-like receptor 7. This receptor helps in immediate recognition that a virus or bacteria is present in the body. Remember, the faster the recognition is, the faster the response.
Essentially, women probably have more toll-like receptor 7 because the gene for this receptor resides in the X chromosome. As we all know, women have two X chromosomes while men only have one.
After the recognition of the disease-causing pathogen, our immune system will further respond. One of those responses is the activation of interferons.
Interferons are aptly named because they “interfere” with the reproduction of the virus. They are proteins that “instruct” our other immune responses.
Some studies indicate that women seem to produce more interferons than men. One of the possible reasons why is that the hormone, estrogen, stimulates the production of these proteins.
Experts state that women seem to produce more antibodies against influenza A virus than men. Moreover, the antibodies produced by women are more “effective” in terms of their ability to attach themselves to the virus. These are the type of antibodies that stop the virus from invading the cells.
COVID-19: Why Do Some Survive and Some Don’t?
While these are the potential reasons why women are more immune against COVID-19 than men, they also agree that the studies behind them are not in the context of the novel coronavirus. Rather, the studies were related to other viruses.
Does COVID affect men more than women? Perhaps, because aside from what seems like a better immune response, there are also other factors to consider regarding men’s “disadvantaged” immunity.
Experts explain that in general, men have the following disadvantages:
There are still a lot of things that we don’t understand about how differently the coronavirus affects men and women. Are women more immune against COVID-19? Studies seem to suggest so.
However, to be on the safe side, always remember that everyone is at risk at some level. For this reason, all of us must follow the safety protocols to slow down and eventually, stop the spread of the virus.
Learn more about COVID-19 here.
Disclaimer
Hello Health Group does not provide medical advice, diagnosis or treatment.
Considering how biological sex impacts immune responses and COVID-19 outcomes
https://www.nature.com/articles/s41577-020-0348-8
Accessed August 28, 2020
Are men suffering more from COVID-19 than women?
https://www.topdoctors.co.uk/medical-articles/why-does-coronavirus-kill-more-men-than-women
Accessed August 28, 2020
Introduction to Immunology Tutorial
http://www.biology.arizona.edu/immunology/tutorials/immunology/page3.html
Accessed August 28, 2020
Sex Differences in COVID-19 Offer a Major Clue
https://medicine.yale.edu/news-article/25385/
Accessed August 28, 2020
COVID-19 kills more men than women. The immune system may be why
https://www.sciencenews.org/article/coronavirus-covid-19-kills-more-men-than-women-why-immune-system
Accessed August 28, 2020
The relationship of COVID-19 severity with cardiovascular disease and its traditional risk factors: A systematic review and meta-analysis
https://www.medrxiv.org/content/10.1101/2020.04.05.20054155v1.full.pdf
Accessed August 28, 2020
Current Version
06/23/2021
Written by Lorraine Bunag, R.N.
Medically reviewed by Ika Villanueva Caperonce, MD
Updated by: Lorraine Bunag, R.N.