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Update Date 03/12/2020 . 4 mins read
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What is Trental used for?

Trental is a brand name for the drug pentoxifylline. Pentoxifylline is a methylxanthine and works by lowering blood viscosity and making blood cells more flexible; both properties are beneficial for treating and preventing blood clots and associated conditions.

It is mainly indicated to:

  • Treat peripheral arterial disease
  • Improve blood flow
  • Increase tissue oxygenation
  • Treat intermittent claudication

How should I take Trental?

Trental is available as an oral tablet. The oral tablet should be taken by mouth without chewing or crushing it. The tablets can be taken with or without food, followed by a glass of water.

How do I store Trental?

This drug should be stored at room temperature (20-25°C) and be protected from light and moisture. Do not freeze this product. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using Trental?

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to pentoxifylline or other methylxanthines (e.g. caffeine, theophylline)
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications, especially warfarin
  • You have underlying health conditions

Is it safe during pregnancy or breastfeeding?

This drug is a pregnancy category C drug. There are no adequate and well-controlled studies using pentoxifylline in pregnant women. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug is excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur when using Trental?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Angina or chest pain
  • Bloating
  • Belching and/or flatulence
  • Dyspepsia
  • Nausea, vomiting
  • Dizziness
  • Headaches
  • Tremors

Rare, serious adverse reactions:

  • Hepatitis
  • Blood abnormalities
    • Anemia
    • Decreased fibrinogen
    • Leukemia
    • Thrombocytopenia
  • Anaphylactic reaction

You may experience some, none, or other side effects not mentioned above. If you experience serious adverse reactions, you must stop taking the drug immediately. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.


What drugs may interact with Trental?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Known drugs and their interactions with medication include:

  • Anticoagulants (e.g. warfarin)
    • Bleeding and/or prolonged prothrombin time
  • Vitamin K antagonists
    • Increased anticoagulant activity
  • Theophylline
    • Increased levels of theophylline leading to toxicity
  • Antihypertensives (i.e. nifedipine, captopril)
    • A slight decrease in blood pressure

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with Trental?

The oral form of this drug should be taken with meals. There are no notable interactions with alcohol with this drug.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with Trental?

This drug should be taken with caution if you have any of the following conditions:

  • Bleeding disorders
  • Recent cerebral or retinal hemorrhage

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Trental.

What is the dose of Trental for an adult?

The usual dosage is one tablet (400 mg) three times a day with meals.

While the effect may be seen within 2 to 4 weeks, it is recommended that treatment be continued for at least 8 weeks. Efficacy has been demonstrated in double-blind clinical studies of 6 months duration.

Digestive and central nervous system side effects are dose-related. If patients develop these effects it is recommended that the dosage be lowered to one tablet twice a day (800 mg/day). If side effects persist at this lower dosage, the administration of TRENTAL should be discontinued.

What is the dose of Trental for a child?

The dose and indication for children have not yet been established. Consult with your doctor or pharmacist for more information.

How is Trental available?

This drug is available in the following dosage forms and strengths:

  • Oral tablet 400 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room. Overdose may occur at ingested doses of 80 mg/kg or higher. Symptoms over overdose may include:

  • Flushing
  • Hypotension
  • Convulsion
  • Somnolence
  • Loss of consciousness
  • Fever
  • Irritability

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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