Toplexil syrup

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Update Date 14/08/2020 . 4 mins read
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Uses

Disclaimer: this brand is not currently available for sale or use in the Philippines. The information provided here is for informational purposes only.

What is Toplexil® (oxomemazine, guaifenesin) used for?

Toplexil® is a preparation that contains the antihistamine oxomemazine and the expectorant guaifenesin. It is indicated for treating cold symptoms such as runny nose and sneezing, and cough accompanied by phlegm.

Oxomemazine is currently not approved by the FDA for use in the US or Philippines.

How should I take Toplexil® (oxomemazine, guaifenesin)?

Take Toplexil® syrup by mouth, using a medical-grade measuring cup or spoon. It can be taken with or without food.

How do I store Toplexil® (oxomemazine, guaifenesin)?

This drug should be stored at room temperature (<30°C) and be protected from light. Do not allow this product to freeze. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal

Precautions & warnings

What should I know before using Toplexil® (oxomemazine, guaifenesin)?

Before using this drug, tell your doctor if you have allergic to any ingredients of this drug.

Because of the photosensitizing effect of phenothiazines, it is preferable to avoid exposure to the sun during treatment.
In children, it is important to rule out bronchial asthma or gastroesophageal reflux before using oxomemazine as an antitussive.

Alcohol increases the sedative effect of H1 antihistamines. Impaired alertness may make driving and machinery operations dangerous. Avoid alcoholic drinks and medicines containing alcohol.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Toplexil® (oxomemazine, guaifenesin)?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Skin rash (including erythema, eczema, purpura, urticaria)
  • Edema (urticaria with sudden swelling of the face and neck which may cause difficulty breathing)
  • Anaphylactic shock
  • Sensitization of the skin to the effects of the sun
  • Fever
  • Abnormal fall in blood platelets (bleeding from the nose or gums)
  • Drowsiness
  • Impaired alertness
  • Impaired memory or concentration
  • Dizziness
  • Motor incoordination
  • Tremor
  • Confusion
  • Hallucinations
  • Dry mouth
  • Visual troubles
  • Retention of urine
  • Constipation
  • Palpitations
  • Low blood pressure

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with Toplexil® (oxomemazine, guaifenesin)?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist

Products that may interact with this drug include:

  • Sedative antidepressants
  • Barbiturates
  • Benzodiazepines
  • Clonidine and related substances
  • Hypnotics
  • Morphine derivatives (analgesics and antitussives)
  • Methadone
  • Neuroleptics
  • Tranquilizers
  • Atropine
  • Imipramine antidepressants
  • Anticholinergic parkinsonism drugs
  • Atropine­like antispasmodics
  • Disopyramide
  • Phenothiazine neuroleptics

Does food or alcohol interact with Toplexil® (oxomemazine, guaifenesin)?

Toplexil® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Toplexil® (oxomemazine, guaifenesin)?

Toplexil® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Orthostatic hypotension
  • Vertigo
  • Sedation
  • Chronic constipation (risk of paralytic ileus)
  • Prostatic hypertrophy
  • Cardio­vascular disorders
  • Severely impaired liver
  • Renal function

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Toplexil® (oxomemazine, guaifenesin).

What is the dose of Toplexil® (oxomemazine, guaifenesin) for an adult?

Adults and children weighing more than 40 kg (i.e. age 12):

The recommended dose is 10 ml per dose, 4 times a day.

What is the dose of Toplexil® (oxomemazine, guaifenesin) for a child?

Children: the daily dosage depends upon the weight of your child:

  • 10 to 20 kg (i.e. age 2 to 6): The recommended dose is 5 ml per dose, 2 to 3 times a day.
  • 20 to 30 kg (i.e. age 6 to 10): The recommended dose is 10 ml per dose, 2 to 3 times a day.
  • 30 to 40 kg (i.e. age 10 to 12): The recommended dose is 10 ml per dose, 3 to 4 times a day.

How is Toplexil® (oxomemazine, guaifenesin) available?

Toplexil® is available in the following dosage forms and strengths:

  • Toplexil® Syrup, 60 ml in brown glass bottle
  • Toplexil® Syrup, 120 ml in brown glass bottle

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Toplexil®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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