Subsyde CR

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Update Date 03/12/2020 . 5 mins read
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What is Subsyde CR (diclofenac Na) used for?

Subsyde CR is commonly used for inflammatory and degenerative forms of:

  • Rheumatism
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Osteoarthritis
  • Spondylarthritis
  • Painful syndromes of the vertebral column
  • Non-articular rheumatism
  • Painful post-traumatic and postoperative inflammation swelling, e.g., following dental or orthopedic surgery
  • Painful and/or inflammatory conditions in gynecology
  • An adjuvant in severe painful inflammatory infections of the ear, nose or throat, e.g., pharyngotonsillitis, otitis

How should I take Subsyde CR (diclofenac Na)?

Take Subsyde CR tablet with a glass of water as advised by your doctor. It is advisable to take after food to avoid gastrointestinal side effects. Swallow it whole, do not chew or crush.

How do I store Subsyde CR (diclofenac Na)?

Subsyde CR is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Subsyde CR in the bathroom or the freezer. There may be different brands of Subsyde CR that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Subsyde CR down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Subsyde CR (diclofenac Na)?

Before using this drug, there is some important information that you may notice:

  • Accurate diagnosis and careful monitoring are essential in patients with gastrointestinal disorders, a history suggestive of peptic ulcer, ulcerative colitis, or Crohn’s disease and in patients with severely impaired hepatic function.
  • Particular caution is called for in patients with impaired cardiac or renal function, as well as in elderly patients.
  • As diclofenac may increase the activity of ≥1 liver enzymes, hepatic function during prolonged treatment should be monitored.
  • This drug is contraindicated with patients who have:
    • Hypersensitivity to any of the excipients of subside CR
    • Peptic ulcer
    • Asthma
    • Urticaria
    • Acute rhinitis

Is it safe during pregnancy or breastfeeding?

In 1st and 2nd trimesters, no controlled studies in pregnant women are available. Diclofenac should not be given during the 3rd trimester because of the risk of premature closure of the ductus arterious and suppression of uterine contractility. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C in 1st and 2nd trimester, D in 3rd trimester according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Subsyde CR (diclofenac Na)?

Some side effects can happen when using this drug, such as:

Gastrointestinal tract: 

  • Occasional: Epigastric pain, other gastrointestinal symptoms e.g., nausea, vomiting, diarrhea, abdominal cramps, dyspepsia, flatulence, and anorexia
  • Rare: GI bleeding, hematemesis, melena, peptic ulcer with or without bleeding or perforation, bloody diarrhea, pancreatitis

Central and peripheral nervous system: 

  • Occasional: Headache, dizziness, vertigo
  • Rare: Tiredness

Skin and subcutaneous tissue: 

  • Occasional: Skin rash
  • Rare: Urticaria

Kidneys (Isolated Cases): 

  • Acute renal failure, hematuria, proteinuria, and interstitial nephritis


  • Occasional: Elevated serum aminotransferase values (SGOT, SGPT)
  • Rare: hepatitis with or without jaundice

Blood (Isolated Cases): 

  • Thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia, aplastic anemia

Hypersensitivity reactions: 

  • Rare: Hypersensitivity reactions e.g., asthma, systemic anaphylactic/anaphylactoid reactions (including hypotension)

Other organ systems: 

  • Rare: edema


What drugs may interact with Subsyde CR (diclofenac Na)?

Subsyde CR may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug including:

  • Aspirin: Concomitant administration of diclofenac and aspirin is not recommended.
  • Anticoagulants: Caution should be exercised while administering anticoagulants with diclofenac since interactions of anticoagulants have been seen with other NSAIDs.
  • Digoxin, Methotrexate, Cyclosporine, and Lithium: Patients who begin taking diclofenac or who increase their diclofenac dose while taking these drugs should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.
  • Oral Hypoglycaemics: Isolated cases have been reported of hypoglycaemic and hyperglycaemic reactions necessitating an adjustment in the dosage of antidiabetic drugs during treatment with diclofenac.
  • Diuretics: Concomitant treatment of diclofenac with potassium-sparing diuretics may raise serum potassium levels, which should be monitored.

Does food or alcohol interact with Subsyde CR (diclofenac Na)?

Subsyde CR may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Food can ease gastric irritation, so it is best to take this drug with a meal. Do not take this drug or other NSAIDs with alcohol as it may increase the risk and severity of gastric ulceration and bleeding.

Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Subsyde CR (diclofenac Na)?

Subsyde CR may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions may include:

  • Gastrointestinal disorders
  • A history of peptic ulcer
  • Ulcerative colitis
  • Crohn’s disease
  • Severely impaired hepatic function
  • Impaired cardiac
  • Renal function
  • Asthma
  • Urticaria
  • Acute rhinitis


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Subsyde CR (diclofenac Na).

What is the dose of Subsyde CR (diclofenac Na) for an adult?

The recommended dose is 1 capsule daily preferably between 6-8 PM (because of circadian rhythm).

What is the dose of Subsyde CR (diclofenac Na) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using it. Please consult with your doctor or pharmacist for more information.

How is Subsyde CR (diclofenac Na) available?

Subsyde CR is available in the following dosage forms and strengths:

  • Capsule, 100 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Subsyde CR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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