Rantudil®

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Published on 22/08/2020 . 5 mins read
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Disclaimer

This drug or supplement is not currently available for sale or use in the Philippines. The information provided here is for informational purposes only.

Uses

What is Rantudil® used for?

Rantudil® (acemetacin) is a nonsteroidal anti-inflammatory drug (NSAID), specifically a non-selective cyclooxygenase (COX) inhibitor. NSAIDs treat various causes of pain, inflammation, and swelling. It can also aid in reducing fever.

COX inhibitors block the action of either or both the COX-1 and COX-1 enzymes. These enzymes convert arachidonic acid into prostaglandin, which is a group of substances that regulate many cellular processes such as platelet aggregation, vasodilation, gastric mucus secretion, and proinflammatory mediators.

Acemetacin is derived from indomethacin, another NSAID. It has less gastric irritating effects than indomethacin.

Rantudil is mainly indicated to treat the following conditions:

  • Inflammation
  • Musculoskeletal pain
  • Arthritis
  • Post-operative pain

How should I take Rantudil?

Rantudil and Rantudil Retard are available as oral capsules. The oral capsules should be swallowed whole without chewing or crushing them. They should be taken with food to prevent gastric irritation.

How do I store Rantudil?

This drug should be stored at room temperature (<30°C) and be protected from light and moisture. Do not store it in the refrigerator or freezer. For safety, keep out of the reach of children and pets.

Always check the label before using this product. Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & Warnings

What should I know before using Rantudil?

NSAIDs, including Rantudil, are associated with an increased risk of bleeding and gastric ulceration. This risk is further increased in older patients usually over 60 years of age, those taking blood thinners, and those with blood clotting disorders.

Some groups of people with conditions like asthma or allergic rhinitis may experience an exacerbation of symptoms after using NSAIDs.

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to Rantudil or other NSAIDs
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications, especially other NSAIDs and blood thinners
  • You have underlying health conditions

Is it safe during pregnancy or breastfeeding?

This drug is not recommended for use during pregnancy and is contraindicated for use during the 3rd trimester. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug may be excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side Effects

What side effects can occur when using Rantudil?

All drugs can elicit side effects even with normal use. Most side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Nausea
  • Diarrhea
  • Stomach upset
  • Abdominal pain
  • Indigestion
  • Headache
  • Dizziness
  • Allergic reaction
    • Rash
    • Pruritis
  • Bronchospasm
  • Blood abnormalities
    • Bleeding
    • Anemia
    • Thrombocytopenia
    • Leukopenia
    • Eosinophilia
  • Edema
  • Eye irritation
  • Photosensitivity
  • Malaise
  • Tinnitus

Seek medical attention immediately if you experience any of these serious, potentially fatal drug reactions:

  • Arterial thrombotic events
    • Myocardial infarction (heart attack)
    • Stroke
  • Gastrointestinal damage
    • Peptic ulceration
    • Bleeding
  • Severe hypersensitivity reaction
    • Fever
    • Toxic epidermal necrolysis (TEN) or Stevens-Johnson Syndrome (SJS)
    • Vasculitis
    • Serum sickness
  • Hepatitis
    • Jaundice
  • Nephrotoxicity
  • Hematologic abnormalities
    • Anemia
    • Thrombocytopenia
    • Leukopenia
    • Agranulocytosis
    • Pancytopenia
  • Seizures

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with Rantudil?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.

Known drugs and their interactions with Rantudil include:

  • Other NSAIDs
    • GI distress
    • Ulceration
  • Salicylates
    • GI distress
  • Anticoagulants
    • Prolonged bleeding
  • Corticosteroids
    • GI bleeding
  • Lithium
    • Decreased elimination
  • Diuretics
    • Decreased sodium excretion
  • Antihypertensives
    • Decreased control of blood pressure
  • Selective serotonin reuptake inhibitors (SSRIs)
    • GI bleeding

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with Rantudil?

Food has no notable effects on Rantudil, however, it is best to take it with meals to prevent gastric irritation. This drug should not be taken with alcohol as it may increase the risk of gastrointestinal ulceration, bleeding, and hepatotoxicity.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with Rantudil?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Active bronchial asthma
  • Uncontrolled hypertension
  • Congestive heart failure (CHF)
  • Other cardiovascular diseases
  • Gastrointestinal diseases
    • Peptic ulcer disease (PUD)
    • Gastroesophageal reflux disease (GERD)
  • Conditions that require surgery
  • Renal or hepatic impairment
  • Women with fertility issues or are undergoing treatment
  • Elderly patients over the age of 60

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult your doctor or pharmacist before using Rantudil.

What is the dose of Rantudil for an adult?

For pain, inflammation, musculoskeletal and joint disorders

  • Take 120 mg per day in divided doses, increase the dose to 180 mg, depending on the response.

Dose adjustments for elderly patients

  • Use the lowest effective dose for the shortest possible duration

What is the dose of Rantudil for a child?

This drug is not recommended for use in children and the recommended dose has not been established. Consult with a doctor or pharmacist for alternatives and more information.

How is Rantudil available?

This drug is available in the following formulations, dosage forms, and strengths:

  • Rantudil® 60 mg capsules
  • Rantudil® Retard 90 mg capsules

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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