Naproxen

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Update Date 14/08/2020 . 7 mins read
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Uses

What is naproxen used for?

Naproxen is part of a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs), specifically a non-selective cyclooxygenase (COX) inhibitor. NSAIDs are used to treat various causes of pain, inflammation, and swelling. It can also aid in reducing fever.

COX inhibitors work by blocking the action of either or both the COX-1 and COX-1 enzymes. These enzymes are responsible for converting arachidonic acid into prostaglandin, which is a group of substances that regulate many cellular processes such as platelet aggregation, vasodilation, gastric mucus secretion, and proinflammatory mediators.

Naproxen is mainly indicated to treat the following conditions:

  • Temporarily relieve minor aches and pains due to:
    • Arthritis
    • Muscle soreness
    • Backache
    • Menstrual cramps
    • Headache
    • Toothache
  • Fever

How should I take Naproxen?

Naproxen is available as an oral capsule and tablet. The oral capsule and tablet should be taken by mouth without chewing or crushing it. The tablets should be taken with food to prevent gastric irritation.

How do I store Naproxen?

This drug should be stored at room temperature (<30°C) and be protected from light and moisture. Do not store it in the refrigerator or freezer. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using naproxen?

NSAIDs, including naproxen, are associated with an increased risk of bleeding and gastric ulceration. This risk is further increased in older patients usually over 60 years of age, those taking blood thinners, and those with blood clotting disorders.

Some groups of people with conditions like asthma or allergic rhinitis may experience an exacerbation of symptoms after using NSAIDs.

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to naproxen or other NSAIDs
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications, especially other NSAIDs and blood thinners
  • You have underlying health conditions

Is it safe during pregnancy or breastfeeding?

This drug is generally not recommended for use during pregnancy and is contraindicated for use during the 3rd trimester. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug may be excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur from naproxen?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Nausea
  • Diarrhea
  • Stomach upset
  • Abdominal pain
  • Indigestion
  • Headache
  • Dizziness
  • Allergic reaction
    • Rash
    • Pruritis
  • Bronchospasm
  • Blood abnormalities
    • Bleeding
    • Anemia
    • Thrombocytopenia
    • Leukopenia
    • Eosinophilia
  • Edema
  • Eye irritation
  • Photosensitivity
  • Malaise
  • Tinnitus
  • Drowsiness
    • Do not take before driving or operating machinery

Seek medical attention immediately if you experience any of these serious, potentially fatal drug reactions:

  • Arterial thrombotic events
    • Myocardial infarction (heart attack)
    • Stroke
  • Gastrointestinal damage
    • Peptic ulceration
    • Bleeding
  • Severe hypersensitivity reaction
    • Fever
    • Toxic epidermal necrolysis (TEN) or Stevens-Johnson Syndrome (SJS)
    • Vasculitis
    • Serum sickness
  • Hepatitis
    • Jaundice
  • Nephrotoxicity
  • Hematologic abnormalities
    • Anemia
    • Thrombocytopenia
    • Leukopenia
    • Agranulocytosis
    • Pancytopenia
  • Seizures

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with naproxen?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.

Known drugs and their interactions with Naproxen include:

  • Other NSAIDs
    • GI distress
    • Ulceration
  • Salicylates
    • GI distress
  • Anticoagulants
    • Prolonged bleeding
  • Corticosteroids
    • GI bleeding
  • Hydantoins
    • Convulsions/seizures
  • Lithium
    • Decreased elimination
  • Diuretics
    • Decreased sodium excretion
  • Methotrexate
    • Increased toxicity
  • Antihypertensives
    • Decreased control of blood pressure
  • Selective serotonin reuptake inhibitors (SSRIs)
    • GI bleeding
  • Sulfonylureas
    • Increased risk of hypoglycemia

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with naproxen?

The absorption rate is slightly decreased with food, however, taking it with a meal prevents gastrointestinal distress. This drug should not be taken with alcohol as it may increase the risk of gastrointestinal ulceration, bleeding, and hepatotoxicity.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with naproxen?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Active bronchial asthma
  • Nasal polyps
  • Rhinitis
  • Uncontrolled hypertension
  • Congestive heart failure (CHF)
  • Other cardiovascular diseases
  • Gastrointestinal diseases
    • Peptic ulcer disease (PUD)
    • Gastroesophageal reflux disease (GERD)
  • Conditions that require surgery
  • Renal or hepatic impairment
  • Women with fertility issues or are undergoing treatment

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using naproxen.

What is the dose of naproxen for an adult?

Usual Adult Dose for Ankylosing Spondylitis

Immediate Release Tablets and Suspension: 250 mg to 500 mg (naproxen) or 275 mg to 550 mg (naproxen sodium) orally twice a day

Controlled Release: 750 mg to 1000 mg orally once a day

Delayed Release: 375 mg to 500 mg orally twice a day

Usual Adult Dose for Osteoarthritis

Immediate Release Tablets and Suspension: 250 mg to 500 mg (naproxen) or 275 mg to 550 mg (naproxen sodium) orally twice a day

Controlled Release: 750 mg to 1000 mg orally once a day

Delayed Release: 375 mg to 500 mg orally twice a day

Usual Adult Dose for Rheumatoid Arthritis

Immediate Release Tablets and Suspension: 250 mg to 500 mg (naproxen) or 275 mg to 550 mg (naproxen sodium) orally twice a day

Controlled Release: 750 mg to 1000 mg orally once a day

Delayed Release: 375 mg to 500 mg orally twice a day

Usual Adult Dose for Acute Gout

Immediate Release Tablets and Suspension:

  • Initial dose: 750 mg (naproxen) or 825 mg (naproxen sodium) orally once on the first day of the attack
  • Following initial dose: 250 mg (naproxen) or 275 mg (naproxen sodium) orally every 8 hours until the attack subsides

Controlled Release: 1000 mg to 1500 mg orally once on the first day of the attack, followed by 1000 mg orally once a day until the attack subsides.

Usual Adult Dose for Bursitis

Immediate Release (naproxen sodium):

  • 550 mg orally once, followed by 275 mg orally every 6 to 8 hours or 550 mg orally every 12 hours as needed
  • Maximum dose: Initial total daily dose not to exceed 1375 mg; thereafter, not to exceed 1100 mg/day

Controlled Release:

  • 1000 mg orally once a day
  • For patients requiring additional analgesia, may increase to 1500 mg orally once a day for a limited time; thereafter, the total daily dose should not exceed 1000 mg/day

Usual Adult Dose for Tendonitis

Immediate Release (naproxen sodium):

  • 550 mg orally once, followed by 275 mg orally every 6 to 8 hours or 550 mg orally every 12 hours as needed
  • Maximum dose: Initial total daily dose not to exceed 1375 mg; thereafter, not to exceed 1100 mg/day

Controlled Release:

  • 1000 mg orally once a day
  • For patients requiring additional analgesia, may increase to 1500 mg orally once a day for a limited time; thereafter, the total daily dose should not exceed 1000 mg/day

Usual Adult Dose for Dysmenorrhea

Immediate Release (naproxen sodium):

  • 550 mg orally once, followed by 275 mg orally every 6 to 8 hours or 550 mg orally every 12 hours as needed
  • Maximum dose: 1375 mg/day initial total daily dose; thereafter, not to exceed 1100 mg/day

Controlled Release:

  • 1000 mg orally once a day
  • For patients requiring additional analgesia, may increase to 1500 mg orally once a day for a limited time; thereafter, the total daily dose should not exceed 1000 mg/day

Over the Counter:

  • 220 mg orally every 8 to 12 hours while symptoms persist
  • May take 440 mg orally once in the first hour if needed
  • Maximum dose: 440 mg (in any 8 to 12 hour period); 660 mg (in any 24 hour period)

Usual Adult Dose for Pain

Immediate Release (naproxen sodium):

  • 550 mg orally once, followed by 275 mg orally every 6 to 8 hours or 550 mg orally every 12 hours as needed
  • Maximum dose: 1375 mg/day initial total daily dose; thereafter, not to exceed 1100 mg/day

Controlled Release:

  • 1000 mg orally once a day
  • For patients requiring additional analgesia, may increase to 1500 mg orally once a day for a limited time; thereafter, the total daily dose should not exceed 1000 mg/day

Over the Counter:

  • 220 mg orally every 8 to 12 hours while symptoms persist
  • May take 440 mg orally once in the first hour if needed
  • Maximum dose: 440 mg (in any 8 to 12 hour period); 660 mg (in any 24 hour period)

Usual Adult Dose for Fever

Over the Counter:

  • 220 mg orally every 8 to 12 hours while symptoms persist
  • May take 440 mg orally once in the first hour if needed
  • Maximum dose: 440 mg (in any 8 to 12 hour period); 660 mg (in any 24 hour period)

What is the dose of naproxen for a child?

Usual Pediatric Dose for Fever

Over the Counter:

  • 12 years or older: 220 mg orally every 8 to 12 hours while symptoms persist
  • May take 440 mg orally once in the first hour if needed
  • Maximum dose: 440 mg (in any 8 to 12 hour period); 660 mg (in any 24 hour period)

Usual Pediatric Dose for Pain

Over the Counter:

  • 12 years or older: 220 mg orally every 8 to 12 hours while symptoms persist
  • May take 440 mg orally once in the first hour if needed
  • Maximum dose: 440 mg (in any 8 to 12 hour period); 660 mg (in any 24 hour period)

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis

Immediate Release Tablets and Suspension:

2 years or older: 5 mg/kg orally twice a day

How is naproxen available?

Naproxen is available in the following brands, dosage forms, and strengths:

  • Flanax 275 mg
  • Flanax Forte tablet 550 mg (Rx-strength)
  • Sarimax film-coated tablet 275 mg, 550 mg (Rx-strength)
  • Skelan tablet 220 mg, 550 mg (Rx-strength)

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of naproxen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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