Enalapril

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Update Date 14/08/2020 . 4 mins read
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Uses

What is enalapril used for?

Enalapril is part of a class of drugs known as antihypertensives, specifically an ACE-inhibitor. By blocking the action of angiotensin-converting enzyme (ACE), there is less of the vasoconstrictor angiotensin II produced. This results in the lowering of blood pressure and sodium and water retention.

Enalapril is mainly indicated to treat the following conditions:

  • Hypertension
  • Heart failure

How should I take enalapril?

Enalapril is available as an oral tablet. The oral tablet should be taken by mouth without chewing or crushing it. The tablets can be taken with or without food. If you have trouble chewing or swallowing tablets, you can crush or divide it and mix it with soft food like yogurt or pudding.

How do I store enalapril?

This drug should be stored at room temperature (<30°C) and be protected from light and moisture. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using enalapril?

ACE-inhibitors, including enalapril, are associated with an increased risk of hypotension and cough. This risk is further increased in older patients usually over 60 years of age, regular alcohol drinkers, and those with respiratory conditions.

Some groups of people with conditions like asthma may experience an exacerbation of symptoms after using ACE-inhibitors.

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to enalapril or other ACE-inhibitors
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications, especially other antihypertensives
  • You have underlying health conditions

Is it safe during pregnancy or breastfeeding?

This drug is a pregnancy category D drug. There is evidence from human studies that shows it can cause fetal harm when taken during pregnancy. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug may be excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur when using enalapril?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Nausea, vomiting, diarrhea
  • Hypotension
  • Persistent dry cough
  • Dizziness
  • Headache
  • Insomnia
  • Peripheral neuropathy
  • Changes in your sense of taste
  • Muscle cramps
  • Rash

Seek medical attention immediately if you experience any of these serious, potentially fatal drug reactions:

  • Angioedema
    • Laryngeal edema
  • Hepatic necrosis (rare)

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with enalapril?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.

Known drugs and their interactions with enalapril include:

  • Other antihypertensives
    • Enhanced hypotension
  • Diuretics
    • Enhanced hypotension
    • Hyperkalemia (with potassium-sparing diuretics)
  • Tricyclic antidepressants (TCAs)
    • Enhanced hypotension
  • Nitrates
    • Enhanced hypotension
  • Anesthesia
    • Enhanced hypotension
  • Lithium
    • Increased risk of lithium toxicity
  • NSAIDs
    • Increased risk of renal impairment

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with enalapril?

There are no notable interactions with food. This drug should not be taken with alcohol as it may increase the severity of hypotension.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with enalapril?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Active bronchial asthma
  • History of angioedema
  • Collagen vascular disease
  • Pre-existing renal insufficiency
  • Renal artery stenosis
  • Aortic or mitral valve stenosis

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using enalapril.

What is the dose of enalapril for an adult?

For hypertension

  • Initial dose: take 5 mg once at bedtime.
    • Dose adjustment for elderly patients: 2.5 mg/day
  • Maintenance dose: take 10-20 mg/day as a single dose.
  • Maximum dose: increase up to 40 mg in 2 divided doses (severe hypertension)

For heart failure

  • Initial dose: take 5 mg once at bedtime.
    • Dose adjustment for elderly patients: 2.5 mg/day
  • Maintenance dose: take 20 mg/day as a single dose or in 2 divided doses.
  • Maximum dose: 40 mg/day in 2 divided doses.

What is the dose of enalapril for a child?

For hypertension

Bodyweight of 20 to <50 kg

  • Initial dose: 2.5 mg once a day
  • Maximum dose: increase up to 20 mg once a day

Bodyweight of >50 kg

  • Initial dose: 5 mg once a day
  • Maximum dose: increase up to 40 mg once a day

How is enalapril available?

This drug is available in the following brands, dosage forms, and strengths:

  • Hypace tablet 5 mg, 10 mg, 20 mg
  • Hypril tablet 5 mg, 10 mg
  • Naprilate tablet 5 mg, 20 mg
  • Renite XL tablet 5 mg, 10 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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