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Update Date 03/12/2020 . 6 mins read
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What is Decapeptyl® (triptorelin) used for?

Decapeptyl® is commonly used for:

  • Prostate cancer (which is locally advanced or has spread to other areas of the body)
  • Endometriosis
  • Fibroids of the uterus
  • Female infertility
  • Precocious (premature) puberty

How should I take Decapeptyl® (triptorelin)?

This medicine contains a solution of triptorelin provided in a pre-filled disposable syringe for single use. It is given as an injection under the skin (subcutaneous) of the lower abdomen.

If your doctor or nurse decides you can give the injections to yourself, they will train you appropriately on the injection technique.

Do not self-inject Decapeptyl® until you are sure of how to do it. The first injection of Decapeptyl® should be under medical supervision.

Follow all instructions given to you by your doctor carefully.

An instruction leaflet is supplied with your medicine and the following information is included:

  • Injecting your medicine.
  • Remove the protective foil and take the syringe out of the blister packaging.
  • Keep the syringe upright with the grey protective cap facing up.
  • Remove the grey protective cap.
  • Gently push the plunger until the first drops of liquid appear at the needle tip.
  • The medicine is to be injected under the skin of the lower abdomen. Clean the injection site with an antiseptic swab immediately prior to injection.
  • Lift up a fold of skin between the thumb and forefinger. With your free hand hold the syringe at a right angle to the skin like a dart and quickly insert the needle all the way into the skin fold. Press down slowly on the plunger to inject the contents of the syringe.
  • Remove the syringe and needle from the skin and discard this immediately into a sharps disposal unit.
  • For each dose, choose a different injection site along the lower abdomen.

Other important information

  • Each pre-filled syringe is for single-use only.
  • Tell your doctor immediately or go to Accident and Emergency at your nearest hospital if you experience signs or symptoms of an allergic reaction (e.g. difficulty in breathing or swelling of the lips).
  • The first injection of this medicine should be supervised by your doctor or nurse.
  • The syringe should be disposed of into a sharps disposal unit.

How do I store Decapeptyl® (triptorelin)?

Decapeptyl®is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Decapeptyl®that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Decapeptyl® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Decapeptyl® (triptorelin)?

Before using this drug, tell your doctor if:

  • You are allergic to any of the active ingredients in Decapeptyl®.
  • You are pregnant.
  • You are breastfeeding.
  • You are allergic to any other substances such as foods, preservatives, or dyes.

Is it safe during pregnancy or breastfeeding?

There is positive evidence that this drug can cause serious birth defects and should never be taken while pregnant under any circumstance. Inform your doctor if you are pregnant or plan to become pregnant if you are currently taking this drug. You may be advised to use contraception while taking this drug.

Decapeptyl® is a pregnancy risk category X, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Decapeptyl® (triptorelin)?

General side effects may include:

  • Pain, redness or inflammation of the skin at the injection site
  • Hot flushes
  • Dizziness
  • Sweating
  • Headache
  • Decreased sex drive
  • Mood changes (including depression)
  • Disturbances of the gut (such as diarrhea, constipation, nausea, vomiting or abdominal pain)
  • Weight changes
  • Visual disturbances
  • Difficulty sleeping (insomnia)
  • Excessive fluid retention in the body tissues, resulting in swelling (edema)
  • Pain in the muscles and joints
  • Increase in blood pressure
  • Decreased bone density
  • Shortness of breath
  • Wheezing
  • Difficulty breathing
  • Swelling of the face, lips, tongue or other parts of the body
  • Rash, itching or hives on the skin

Side effects in men may include:

  • Problems with getting an erection (erectile dysfunction) or ejaculation
  • Abnormal enlargement of breasts (gynecomastia)
  • Feeling weak or tired

Side effects in women may include:

  • Vaginal dryness
  • Painful sex
  • Breast pain

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Decapeptyl® (triptorelin)?

Decapeptyl® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Decapeptyl® (triptorelin)?

Decapeptyl® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Decapeptyl® (triptorelin)?

Decapeptyl® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially a mild to severe liver disease.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Decapeptyl® (triptorelin).

What is the dose of Decapeptyl® (triptorelin) for an adult?

Decapeptyl® SR injection is a long-acting injection that is administered into a muscle (intramuscularly), usually in the buttock. The site that this injection is given into should be varied periodically.

To treat prostate cancer triptorelin is given as a monthly, three-monthly, or six-monthly injection. The triptorelin may increase testosterone levels and so it may cause an initial temporary tumor ‘flare’, with symptoms such as urinary obstruction and bone pain, before cancer begins to shrink. Some men may be particularly prone to these symptoms. If this applies to you, your doctor will also treat you with another type of anti-cancer medicine, known as an anti-androgen (eg cyproterone acetate or flutamide) to prevent this. The anti-androgen will be started three days before the triptorelin and continued for the first two to three weeks of treatment.

To treat endometriosis, triptorelin is given as a monthly or three-monthly injection for up to six months, starting in the first five days of the menstrual cycle (day one is the first day of your period).

To treat fibroids, an injection of triptorelin is given every month, again starting in the first five days of the menstrual cycle, for a minimum of three months up to a maximum of six months.

As with the treatment of prostate cancer in men, administration of triptorelin in women may cause a temporary increase in symptoms in the first few days after the injection, due to the initial rise in estrogen levels. This improves as the estrogen levels decrease.

What is the dose of Decapeptyl® (triptorelin) for a child?

To treat premature puberty triptorelin is given as a three-monthly injection. Treatment is stopped around the usual age for reaching puberty and should not be continued beyond when bone development has reached that expected in girls aged 12 years and boys aged 13 to 14 years.

How is Decapeptyl® (triptorelin) available?

Decapeptyl® is available in the following dosage forms and strengths:

  • Decapeptyl® CR injection 3.75 mg (single-dose kit)

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Decapeptyl®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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