Cefpodoxime

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Update Date 14/08/2020 . 4 mins read
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Uses

What is cefpodoxime used for?

Cefpodoxime is part of a class of antibiotics known as cephalosporins, specifically the 3rd generation of cephalosporins. Cephalosporins are chemically-related to penicillins and work by binding to penicillin-binding proteins (PBPs) that are embedded on certain bacterial cell walls. This binding prevents normal crosslinking and results in a weakened cell wall that ruptures and kills the bacteria. Cephalosporins have the added property of β-lactamase resistance, which increases their efficacy against certain bacteria.

It is a broad-spectrum antibiotic mainly indicated to treat the following bacterial infections:

  • Respiratory tract infections (RTIs)
  • Urinary tract infections (UTIs)
  • Skin and soft tissue infections
  • Uncomplicated gonorrhea

The antimicrobial spectrum of activity of amoxicillin includes most Gram-positive and Gram-negative bacteria, except:

  • Pseudomonas aeruginosa
  • Enterococcus
  • Bacteroides fragilis

How should I take cefpodoxime?

Cefpodoxime is available as an oral suspension and tablet. The oral tablet should be taken by mouth without chewing or crushing it. The oral suspension requires reconstitution with clean drinking water. cefpodoxime should be taken with food, followed by a glass of water.

How do I store cefpodoxime?

This drug should be stored at room temperature (20-25°C) and be protected from light and moisture. Do not freeze this product. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency. Keep reconstituted suspensions in the refrigerator (2-8°C) for up to 10 days.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using cefpodoxime?

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to cephalosporins or penicillins
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications
  • You have underlying health conditions

Is it safe during pregnancy or breastfeeding?

This drug is a pregnancy category B drug. There are no adequate and well-controlled studies using amoxicillin in pregnant women, however, animal studies show no risk to the fetus. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug is excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur when using cefpodoxime?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Nausea, vomiting
  • Diarrhea
  • Diaper or skin rash
  • Mild allergic reaction
  • Vaginal infection
  • Nosebleed
  • Nightmares
  • Anxiety
  • Tinnitus

Rare, serious adverse reactions:

  • Anaphylactic reaction
  • Clostridium difficile-associated diarrhea
  • Colitis

You may experience some, none, or other side effects not mentioned above. If you experience serious adverse reactions, you must stop taking the drug immediately. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with cefpodoxime?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Known drugs and their interactions with medication include:

  • Antacids
    • Decreased absorption and effect of cefpodoxime
  • Probenecid
    • May result in decreased renal excretion of cefpodoxime

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with cefpodoxime?

This drug can be taken with meals, as this improves the absorption of cefpodoxime. There are no notable interactions with alcohol with this drug.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with cefpodoxime?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • Renal impairment
  • Clostridium difficile-associated diarrhea

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using cefpodoxime.

What is the dose of cefpodoxime for an adult?

For treating RTIs and UTIs

  • Take 100-200 mg every 12 hours.

For treating skin and soft tissue infections

  • Take 200-400 mg every 12 hours.

For treating uncomplicated gonorrhea

  • Take 200 mg as a single dose

What is the dose of cefpodoxime for a child?

For treating RTIs and UTIs

  • Age >15 days: give 4 mg/kg every 12 hours.
  • Maximum dose: 200 mg per day

For treating skin and soft tissue infections

  • Age >15 days: give 4 mg/kg every 12 hours.
  • Maximum dose: 200 mg per day

For treating acute otitis media

  • Age >15 days: give 4 mg/kg every 12 hours.
  • Maximum dose: 200 mg per day

How is cefpodoxime available?

This drug is available in the following brands, dosage forms, and strengths:

  • Switch film-coated tablet 200 mg
  • Trizef film-coated tablet 100 mg
  • Trizef granules for oral suspension 50 mg/5 mL
  • Zuderm film-coated tablet 100 mg, 200 mg
  • Zuderm granules for oral suspension 50 mg/5 mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room. Symptoms of overdose may include:

  • Severe allergic reaction
  • Severe GI distress

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose. Avoid missing doses to prevent antibiotic resistance and treatment failure.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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