Cefadroxil

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Update Date 14/08/2020 . 4 mins read
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Uses

What is cefadroxil used for?

Cefadroxil is part of a class of antibiotics known as cephalosporins, specifically a first-generation cephalosporin. Cephalosporins are chemically related to penicillin, and work by binding to penicillin-binding proteins (PBPs) that are embedded on certain bacterial cell walls. This binding prevents normal crosslinking and results in a weakened cell wall that ruptures and kills the bacteria.

Cephalosporins have the same mechanism as penicillin, however, have enhanced resistance against β-lactamases.

Cefadroxil is a broad-spectrum antibiotic mainly indicated for:

  • Skin and skin structure infections
  • Urinary tract infections (UTIs)
  • Pharyngitis
  • Tonsillitis

The antimicrobial spectrum of activity of cefadroxil includes:

Gram-positive bacteria

  • Staphylococcus spp

Including:

  • methicillin-susceptible Staphylococcus aureus (MSSA)
  • coagulase-negative Staphylococci
  • Streptococcus spp

Including:

  • Streptococcus pneumoniae

Aerobic Gram-negative

  • Escherichia coli
  • Moraxella catarrhalis
  • Klebsiella pneumoniae
  • Proteus mirabilis

How should I take cefadroxil?

Cefadroxil is available as an oral capsule and syrup. The oral capsule should be taken by mouth and swallowed whole, without chewing or crushing. The oral syrup should be measured with a medical-grade cup or spoon. This medication can be taken with or without food.

How do I store cefadroxil?

This drug should be stored at room temperature (20-25°C) and be protected from light and moisture. Do not freeze this product. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using cefadroxil?

Before using this medication, inform your doctor if:

  • You have ever had an allergic reaction to cefadroxil or other cephalosporins
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications
  • You have underlying health conditions

Is it safe during pregnancy or breastfeeding?

This drug is a pregnancy category B drug. There are no adequate and well-controlled studies using cefadroxil in pregnant women, however, animal studies show no risk to the fetus. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug is excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur when using cefadroxil?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential side effects while using this drug include:

  • Nausea, vomiting
  • Diarrhea
  • Colitis
  • Mild allergic reaction

Rare, serious adverse reactions:

  • Hepatitis
  • Nephrotoxicity
  • Blood abnormalities
  • Anaphylactic reaction
  • Convulsions

You may experience some, none, or other side effects not mentioned above. If you experience serious adverse reactions, you must stop taking the drug immediately. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with cefadroxil?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Known drugs and associated interactions with this medication include:

  • Bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol)
    • Antagonistic effect
  • Warfarin
    • Enhanced anticoagulant effect
  • Sodium picosulfate
    • Decreased therapeutic effect of this drug
  • BCG and typhoid vaccine
    • Decreased therapeutic effect of these vaccines
  • Fosphenytoin and phenytoin
    • Decreased protein binding of these drugs
  • Probenecid
    • Decreased clearance of cefadroxil
  • Aminoglycosides
    • Increased nephrotoxicity
  • Polymyxin B
    • Increased nephrotoxicity
  • Colistin
    • Increased nephrotoxicity
  • Loop diuretics
    • Increased nephrotoxicity
  • Oral contraceptives
    • Decreased effectivity of contraception
  • Cholestyramine
    • Reduced bioavailability of cefadroxil

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with cefadroxil?

This drug can be taken with or without meals, as there is no notable interaction. There are no notable interactions with alcohol, however, a disulfiram-like reaction is possible with other cephalosporins.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with cefadroxil?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • History of hypersensitivity to penicillins
  • Renal impairment
  • GI disease
    • Colitis
    • Clostridium difficile-associated diarrhea
  • Seizure disorder

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using cefadroxil.

What is the dose of cefadroxil for an adult?

For treating susceptible infections

  • Administer 1 to 2 g per day as a single dose or in 2 divided doses

Dose adjustment for renal impairment

Patients undergoing dialysis: administer and additional 0.5 to 1 g after each dialysis session

Creatinine clearance (CrCl)

  • < 10: administer 0.5 to 1 g every 36 hours
  • 11-25: administer 0.5 to 1 g every 24 hours
  • 26-50: administer 0.5 to 1 g every 12 hours

What is the dose of cefadroxil for a child?

For treating susceptible infections

Administer 1 to 2 g per day as a single dose or in 2 divided doses

  • Ages >6 years or <40 kg bodyweight: administer 30-50 mg/kg per day as a single dose or in 2 divided doses
  • Maximum dose: up to 100 mg/kg per day

How is cefadroxil available?

This drug is available in the following brands, dosage forms, and strengths:

  • Drozid capsule 500 mg
  • Drozid syrup 125 mg/5 mL
  • Wincocef-500 capsule 500 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose. Avoid missing doses to prevent antibiotic resistance and treatment failure.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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