Candesartan

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Update Date 11/05/2020 . 7 mins read
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Uses

What is Candesartan used for?

Candesartan is commonly used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Candesartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so blood can flow more easily.

This medication is also used to treat heart failure.

This medication is not recommended for use in children younger than 1 year due to increased risk of side effects.

How should I take Candesartan?

Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily.

The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on weight

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. For the treatment of high blood pressure, it may take up to 6 weeks before you get the full benefit of this drug.

Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase).

How do I store Candesartan?

Candesartan is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Candesartan in the bathroom or the freezer. There may be different brands of Candesartan that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Candesartan down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Candesartan?

Before taking candesartan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, high blood levels of potassium in the blood (hyperkalemia), loss of too much body water and/or minerals (dehydration).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Too much sweating, diarrhea, or vomiting may cause you to feel lightheaded. Report prolonged diarrhea or vomiting to your doctor.

This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness, increases in potassium level, and change in the amount of urine (kidney problems).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details. (See also Warning section.)

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

Please always consult with your doctor to weigh the potential benefits and risks before taking this Candesartan. This Candesartan is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

It is not recommended to take this medication while pregnant as there is data from studies that suggests it can cause harm or deformation to the fetus.

Side effects

What side effects can occur from Candesartan?

Dizziness, tiredness, or lightheadedness may occur as your body adjusts to the medication. Runny nose or sore throat may also occur. If any of these effects persists or worsens, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: fainting, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat).

Although candesartan may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking candesartan. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Candesartan?

Some products that may interact with this drug include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as ACE inhibitors including benazepril/lisinopril, birth control pills containing drospirenone).

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Candesartan may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Candesartan?

Candesartan may interact with food or alcohol by altering the way the drug works or increasing the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Candesartan?

Candesartan may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Candesartan.

What is the dose of Candesartan for an adult?

Usual Adult Dose for Hypertension

Initially: 8 mg once daily adjusted according to response. 

Maintenance: 8 mg once daily. 

Max: 32 mg/day as single or in 2 divided doses. 

Patients w/ intravascular volume depletion: 

Initially, 4 mg once daily.

Usual Adult Dose for Congestive Heart Failure

Initially: 4 mg once daily, may be doubled at intervals of not more than 2 weeks. 

Max: 32 mg once daily.

Renal Dose Adjustments

Adult: No adjustment recommended

Liver Dose Adjustments

Adult:

-Mild liver dysfunction (Child-Pugh A): No adjustment recommended

-Moderate liver dysfunction (Child-Pugh B): Initial dose: 8 mg orally once a day

-Severe liver dysfunction (Child-Pugh C): Data not available

What is the dose of Candesartan for a child?

Usual Pediatric Dose for Hypertension

1 TO LESS THAN 6 YEARS:

Initial dose: 200 mcg/kg/day orally in 1 to 2 divided doses. May increase according to response to 50-400 mcg/kg/day.

Maintenance dose: 0.05 to 0.4 mg/kg/day orally in 1 to 2 divided doses

6 TO LESS THAN 17 YEARS:

Less than 50 kg body weight:

-Initial dose: 4 to 8 mg/day orally in 1 to 2 divided doses

-Maintenance dose: 2 to 16 mg/day orally in 1 to 2 divided doses

Greater than 50 kg body weight:

-Initial dose: 8 to 16 mg/day orally in 1 to 2 divided doses

-Maintenance dose: 4 to 32 mg/day orally in 1 to 2 divided doses

Comments:

-For patients with possible intravascular volume depletion (e.g., patients treated with diuretics, especially those with renal impairment), initiate this drug under close supervision and consider administration of a lower dose.

-Antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 weeks of starting that dose.

-For children unable to swallow tablets, an extemporaneous suspension may be used instead.

Renal Dose Adjustments

Pediatric:

-GFR 30 mL/min/1.73 m2 or greater: Data not available

-GFR less than 30 mL/min/1.73 m2: Not recommended

How is Candesartan available?

Candesartan is available in the following brand(s), dosage forms, and strengths:

  • Atasart(R) tablets: 8 mg, 16 mg
  • Torcand(R) tablets: 8 mg, 16 mg
  • Casartan tablets: 8 mg, 16 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Candesartan, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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