Calcium gluconate

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Update Date 14/08/2020 . 4 mins read
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Uses

What is calcium gluconate used for?

Calcium gluconate is part of a class of drugs known as electrolytes, which are necessary for cellular functions such as muscle contractions and nerve impulses. Electrolytes are used to treat and correct electrolyte imbalances due to various conditions, including dehydration, excessive vomiting or diarrhea, and diabetic ketoacidosis

Electrolytes are different elements that carry a charge (electrons) and can be either positively charged (cations) or negatively charged (ions). Common examples of electrolytes include calcium, sodium, magnesium, potassium, chloride, and phosphate.

Calcium gluconate is mainly indicated to treat the following conditions:

  • Hypocalcemia (low blood calcium levels)
  • Hypocalcemic tetany
  • Hypermagnesemia (high blood magnesium levels)

How should I take calcium gluconate?

Calcium gluconate is available as a parenteral solution for injection. It is injected through the intravenous (IV) or intramuscular (IM) route and should not be taken as an oral solution. The dose must be administered slowly to prevent injection site irritation and adverse effects. It should be administered by a licensed health professional.

How do I store calcium gluconate?

This drug should be stored at room temperature (<25°C) and be protected from light and moisture. Do not allow this product to freeze. Always check the label before using this product. For safety, keep out of the reach of children and pets.

Do not use if the printed expiration date has passed, the product seal has been broken, or the product has changed in color, odor, or consistency.

Do not dispose of this product by pouring it down the drain, toilet, or into the environment. Ask your pharmacist regarding the proper way and location of disposal.

Precautions & warnings

What should I know before using calcium gluconate?

Before using this medication, inform your doctor if:

  • You have ever had an adverse reaction to calcium gluconate
  • You have a history of allergy to other medications, food, or other substances
  • You are taking other medications, especially other sources of calcium or vitamin D
  • You have underlying health conditions, such as cardiovascular disease

Is it safe during pregnancy or breastfeeding?

Calcium gluconate passes through the placenta and may be more concentrated in fetal blood compared to maternal blood. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by your doctor.

This drug may be excreted in breast milk. This drug should be used while breastfeeding only if the potential benefit justifies the potential risk to the child, as determined by your doctor.

Side effects

What side effects can occur when using calcium gluconate?

All drugs have the potential to elicit side effects even with normal use. Many side effects are dose-related and will resolve when it is adjusted or at the end of therapy.

Potential adverse effects while using this drug include:

  • Cardiovascular disorders
    • Hypotension (low blood pressure)
    • Bradycardia (slow heart rate)
    • Arrhythmia
    • Vasodilation
    • Flushing
    • Vasomotor collapse *potentially fatal
  • Gastrointestinal disturbances
  • Feeling warm or hot
  • Sweating
  • Injection site reactions
    • Redness
    • Abscess formation
    • Tissue induration
    • Tissue necrosis
    • Soft tissue calcification

You may experience some, none, or other side effects not mentioned above. If you have any concerns about a side effect or it becomes bothersome, consult your doctor or pharmacist.

Interactions

What drugs may interact with calcium gluconate?

This drug may interact with other medications. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and inform your doctor and pharmacist.

Known drugs and their interactions with calcium gluconate include:

  • Cardiac glycosides (e.g. digoxin)
    • Increased risk of toxicity
  • Epinephrine
    • Increased risk of arrhythmia
  • Magnesium
    • Antagonistic effect on both drugs
  • Calcium channel blockers (e.g. verapamil, amlodipine)
    • Antagonistic effect against these drugs
  • Thiazide diuretics
    • Increased calcium levels

This drug is incompatible with the following:

  • Oxidizing agents
  • Citrates
  • Bicarbonates
  • Oxalates
  • Phosphates
  • Sulfates
  • Amphotericin
  • Cephazolin Na
  • Cephamandole nafate
  • Novobiocin Na
  • Dobutamine HCl
  • Prochlorperazine
  • Tetracyclines

If you experience an adverse drug interaction, stop taking this drug and continue taking your other medication. Inform your doctor immediately to reevaluate your treatment plan. Your dose may need to be adjusted, substituted with another drug, or discontinue using the drug.

Does food or alcohol interact with calcium gluconate?

There are no significant food or alcohol interactions with this drug.

Inform your doctor or pharmacist if you have any concerns regarding food-drug interactions.

What health conditions may interact with calcium gluconate?

This drug should be taken with caution if you have any of the following conditions or risk factors:

  • History of calcium renal calculi (kidney stones)
  • Impaired renal function
  • Cardiac disease
  • Sarcoidosis

Inform your doctor or pharmacist if you have any concerns regarding specific health conditions.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using calcium gluconate.

What is the dose of calcium gluconate for an adult?

As an antidote for severe hypermagnesemia and to treat severe hyperkalemia

  • Administer 10 ml of 10% calcium gluconate solution over 2 minutes, repeated every 10 minutes if needed.

To treat hypocalcemic tetany and severe acute hypocalcemia

  • Administer 2.25 mmol by slow IV injection over 10 minutes, followed by 58-77 ml of 10% calcium gluconate solution in 0.5-1L of 5% dextrose solution as a continuous IV infusion.

What is the dose of calcium gluconate for a child?

As an antidote for severe hypermagnesemia and to treat severe hyperkalemia

  • Age 0 to 18 years: 0.5 ml/kg of 10% calcium gluconate solution as a single dose.
  • Maximum dose: 20 ml of 10% calcium gluconate solution.

To treat hypocalcemic tetany and severe acute hypocalcemia

  • Age 0 to 18 years: 0.5 ml/kg of 10% calcium gluconate solution as a single dose.
  • Maximum dose: 20 ml of 10% calcium gluconate solution.

How is calcium gluconate available?

This drug is available in the following brands, dosage forms, and strengths:

  • Calcinate solution for injection 100 mg/mL (10% w/v)
  • Phil Pharmawealth calcium gluconate solution for injection 100 mg/mL (10% w/v)
  • Euro-Med calcium gluconate 100 mg/mL (10% w/v)

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room. Symptoms of overdose include:

  • Hypercalcemia
  • Anorexia
  • Nausea
  • Vomiting
  • Constipation
  • Abdominal pain
  • Polyuria
  • Polydipsia
  • Dehydration
  • Muscle weakness
  • Bone pain
  • Confusion
  • Hypertension
  • Arrhythmias
  • Cardiac arrest
  • Coma

What should I do if I miss a dose?

If you miss a dose of this drug, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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