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Natrilix/Natrilix SR (diuretic, antihypertensive agent)

Natrilix and Natrilix SR are brand names of the generic drug indapamide. Indapamide is a diuretic or “water pill”. It works in the kidneys and promotes sodium and water excretion in the urine, thus removing extra water from the body.



What is Natrilix used for?

  • Edema due to heart failure
  • Hypertension
  • Calcium nephrolithiasis

How should I take Natrilix?

Swallow the tablet whole without chewing, crushing, or dissolving it in liquid. Take it with or without meals. This drug may cause you to urinate more frequently.

How do I store Natrilix?

This product is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer.

There may be different brands of this drug that may have different storage needs. So, it is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. Additionally, it is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & Warnings

What should I know before using Natrilix?

Before using this drug, tell your doctor if you are/have:

  • Pregnant or breastfeeding.
  • Taking any other medicines. This includes any prescription, OTC, and herbal remedies.
  • An allergy to any of the ingredients of this product.
  • Any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

Unfortunately, there isn’t enough information about the safety of using this drug during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking any medication.

Side Effects

What side effects can occur from Natrilix?

Like all drugs, this product may have side effects. If they occur, side effects are generally mild and resolve once treatment is finished or the dose is lowered. Some reported side effects include:

  • Allergic reaction
  • Hypokalemia
  • Weakness, fatigue
  • Muscle cramps
  • Heart palpitations

However, not everyone experiences these side effects. In addition, some people may experience other side effects. So, if you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Natrilix?

This medication may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects.

To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist.

Drugs with known interactions:

  • Lithium
  • Antiarrhythmic drugs
  • Antipsychotics
  • Erythromycin
  • Quinolones
  • NSAIDs
  • ACE inhibitors
  • Amphotericin B
  • Steroids
  • Laxatives
  • Allopurinol
  • Potassium-sparing diuretics
  • Metformin
  • Ciclosporin, tacrolimus

If you experience an adverse drug interaction, inform your doctor immediately to reevaluate your treatment plan. Approaches include dose adjustment, drug substitution, or ending therapy.

Does food or alcohol interact with Natrilix?

This drug may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Natrilix?

This drug may interact with underlying conditions. This interaction may worsen your health condition or alter the way the drug works. Therefore, it is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Severe renal failure
  • Severe liver impairment
  • Hepatic encephalopathy
  • Hypokalemia


The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

Essential hypertension

Take one tablet once a day, preferably in the morning.

What is the dose for a child?

There is no established pediatric dose. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Natrilix available?

Natrilix is available in the following dosage forms and strengths:

  • Tablet: 2.5 mg
  • Sustained-release: 1.5 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Natrilix SR https://www.mims.com/philippines/drug/info/natrilix%20sr Accessed June 28, 2021

Natrilix https://www.nps.org.au/medicine-finder/natrilix-tablets Accessed June 28, 2021

Natrilix SR https://www.nps.org.au/medicine-finder/natrilix-sr-sustained-release-tablets Accessed June 28, 2021

Package Leaflet: Natrilix SR http://www.hpra.ie/img/uploaded/swedocuments/7375f31c-d753-4fab-a2b8-b8ff9ee7c9e6.pdf Accessed June 28, 2021

Indapamide. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed June 28, 2021. http://online.lexi.com

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Written by Stephanie Nicole Nera, RPh, PharmD Updated Jun 28