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Feburic (febuxostat, anti-gout agent)

Uses|Precautions & warnings|Side effects|Interactions|Dosage

Feburic is the brand name of the drug febuxostat. Febuxostat is a xanthine oxidase inhibitor for treating gouty arthritis. It works by blocking an enzyme in the body (xanthine oxidase), which lowers levels of uric acid in the body. Febuxostat is mainly used in patients who do not respond well to allopurinol or cannot take it.




What is Feburic used for?

Feburic (febuxostat) treats conditions of chronic hyperuricemia or high uric acid levels in the blood where urate crystals have deposited into joints and other areas of the body, such as gouty arthritis.

How should I take Feburic?

Take febuxostat by mouth with or without food. Swallow the tablet whole, without crushing, chewing, or dissolving the tablet. Continue to take febuxostat even if you feel well. Avoid missing doses to prevent flare-ups.

How do I store Feburic?

Feburic is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store it in the bathroom or the freezer. There may be different brands of febuxostat that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush this product down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Feburic?

Before using this drug, tell your doctor if you are/have:

  • Allergic to any ingredient in Feburic
  • Asymptomatic gout
  • High blood uric acid levels caused by a condition other than gout (e.g., Lesch-Nyhan syndrome, cancer or treatment of cancer, organ transplant).
  • You are taking azathioprine, didanosine, or mercaptopurine.

Also, there is important safety information that you should notice:

  • Some patients may experience a gout flare-up when they start taking febuxostat. Your doctor may prescribe a nonsteroidal anti-inflammatory drug (NSAID) or colchicine to take to help control or prevent a gout flare-up. If you experience a gout flare-up, do not stop taking febuxostat without talking to your doctor. Talk with your doctor if you have any questions or concerns.
  • Lab tests, including uric acid levels and liver function, may be performed while you take febuxostat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Febuxostat should be used with extreme caution in children younger than 18 years old; safety and effectiveness in these children have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using febuxostat during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this drug.

Febuxostat is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Feburic?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness)
  • Blood in the urine or stools
  • Chest, jaw, or arm pain
  • Confusion
  • Coughing or vomiting blood
  • Decrease in the amount of urine produced
  • Fainting
  • Fast, slow, or irregular heartbeat
  • Fever, chills, or persistent sore throat
  • Hearing loss
  • Mental or mood changes
  • Muscle pain or cramps
  • One-sided weakness
  • Red, swollen, blistered, or peeling skin
  • Shortness of breath
  • Sudden, severe nausea or vomiting
  • Symptoms of high or low blood pressure (e.g., headache, dizziness, tiredness, weakness)
  • Symptoms of liver problems (e.g., yellowing of the skin or eyes; dark urine; pale stools; right-sided stomach pain; loss of appetite; unusual nausea or tiredness)
  • Slurred speech
  • Stomach pain
  • Unusual bruising or bleeding
  • Unusual sweating or weakness
  • Vision problems (e.g., blurred vision)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Feburic?

Feburic may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Especially, if you are taking azathioprine, didanosine, mercaptopurine, and theophylline because the risk of their side effects may be increased by febuxostat.

Does food or alcohol interact with Feburic?

Feburic may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Feburic?

Feburic may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions may include:

  • Liver or kidney problems
  • A history of heart problems (e.g., a heart attack)
  • A stroke


The information provided is not a substitute for any medical advice. Therefore, you should always consult with your doctor or pharmacist before using any medication.

What is the dose for an adult?

80 mg once daily. May be increased to 120 mg once daily if serum uric acid is >6 mg/dL (357 μmol/L) after 2 to 4 weeks. It may be administered with or without food, and it can be taken with antacids.

Flares of gout may increase after febuxostat is started as uric acid moves out of tissues. These gout flares may be prevented with non-steroidal anti-inflammatory drugs (e.g. ibuprofen, naproxen) or colchicine.

What is the dose for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Feburic available?

Feburic is available in the following dosage forms and strengths:

  • Film-coated tablet 80 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Feburic https://www.mims.com/philippines/drug/info/feburic?type=full Accessed May 31, 2021

Febuxostat (Uloric) for Hyperuricemia and Gout https://www.aafp.org/afp/2010/0515/p1287.html Accessed May 31, 2021

Febuxostat https://pubchem.ncbi.nlm.nih.gov/compound/Febuxostat Accessed May 31, 2021

Feburic https://www.astellas.com/ph/product/feburicr Accessed May 31, 2021

Febuxostat (Oral Route) https://www.mayoclinic.org/drugs-supplements/febuxostat-oral-route/description/drg-20074780 Accessed May 31, 2021

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Written by Stephanie Nicole Nera, RPh, PharmD Updated May 31